Dr. Hans Renata, Associate Professor at Rice University will be giving a seminar at Caltech on Friday, January 13, 2023 at 2:00PM. Dr. Renata will give a talk about his research followed by a personal talk focusing on his journey into science. This seminar is hosted by the Donna and Benjamin M Rosen Bioengineering Center at Caltech.
Title: Combining Synthetic Chemistry and Biology for Streamlining Access to Complex Molecules
Abstract: By virtue of their unrivaled selectivity profiles, enzymes possess remarkable potential to address unsolved challenges in chemical synthesis. The realization of this potential, however, has only recently gained traction. Recent advances in enzyme engineering and genome mining have provided a powerful platform for identifying and optimizing enzymatic transformations for synthetic applications and allowed us to begin formulating novel synthetic strategies and disconnections. This talk will describe our recent efforts in developing a new design language in chemical synthesis that centers on the incorporation of biocatalytic approaches in contemporary synthetic logic. Case studies will focus on the use of this platform in the chemoenzymatic syntheses of complex natural products and also highlight how this platform could serve as a starting point to enable further biological and medicinal chemistry discoveries.
Bio: Hans Renata was born in Surabaya, Indonesia. After completing his high school education in Singapore, he moved to the US and received his B.A. degree from Columbia University in 2008, conducting research under the tutelage of Professor Tristan H. Lambert. He earned his Ph.D. from The Scripps Research Institute in 2013 under the guidance of Professor Phil S. Baran. In his graduate thesis, Hans completed the synthesis of a polyhydroxylated cardiac glycoside, ouabagenin, and developed a range of corticosteroid analogues bearing hydroxylation at the C19 position. In 2013, he began his postdoctoral studies in the laboratory of Professor Frances H. Arnold at the California Institute of Technology. Hans joined the faculty at The Scripps Research Institute Florida in the summer of 2016 and was promoted to the rank of associate professor with tenure in 2022. In July 2022, Hans moved his laboratory to Rice University, where he is currently a faculty member.
Follow this link to view the recorded talk. Please note: This talk recording is available to Caltech personnel only. Caltech-access credentials are required to view. Broadband connection is recommended for optimum quality.
